CEACAM5 and Familial prostate cancer: A recombinant MVA-expressing human 5T4 (MVA-h5T4), called TroVax for metastatic castration-resistant prostate cancer, and a recombinant attenuated vaccinia virus (rVV) vaccine or fowlpox virus (rFV) against human carcinoembryonic antigen (c-VV-CEA) with or without a triad of co-stimulatory adhesion molecules (TRICOM) are great examples that were tested in the clinical setting101,102.