The first and only FDA-approved cell-based therapy for metastatic prostate cancer, sipuleucel-T, contains a variety of cells, including B cells, monocytes, DCs, and NK cells, that are cultured and processed in the presence of prostatic acid phosphatase (PAP) fused with granulocyte-macrophage colony-stimulating factor (GM-CSF) for 2 days following leukapheresis in designated apheresis centers1,126. The gene discussed is ACP3; the disease is metastatic prostate carcinoma.