Group 2 includes Alpha1 acid glycoprotein1, Apolipoprotein A1, Zinc alpha 2 glycoprotein, Alpha 1 Microglobulin/Bikunin Precursor appear in late years of T2DM (at least in our patients) i.e. 10–15 and 15–20 years. This evidence concerns the gene AMBP and type 2 diabetes mellitus.