Jain et al. found 3 LMWPs namely Alpha 1 Microglobulin/Bikunin Precursor (A1M), Alpha1 acid glycoprotein1 (A1AG1) and Zinc alpha 2 glycoprotein (ZA2G) capable of discriminating diabetic nephropathy from control subjects but they could not recognize the precise stage of renal injury these LMWPs were excreted [21], whereas, we observed A1AG1, Apolipoprotein A1 (ApA1), ZA2G and A1M appeared in late years of T2DM, i.e., 10–15 and 15–20 years. Here, APOA1 is linked to type 2 diabetes mellitus.