Out of which four proteins (Ig light chains, transthyretin, cystatin c and ubiquitin) either individually or in combination can prove as potential low molecular weight candidates capable of diagnosing early diabetic nephropathy as early as 0–5 years of T2DM and 5–10 years of T2DM but their validation in large number of population is to be verified. This evidence concerns the gene CST3 and type 2 diabetes mellitus.