They reported that A1M levels were highest amongst the subjects on insulin treatment which correlated with our observations, where we found that subjects with 15–20 years of T2DM duration (late years of T2DM) also were dependent more on insulin treatment for controlling hyperglycemia (≈ 30.8% subjects) in comparison to other T2DM patients w/o secondary complications. Here, INS is linked to Hyperglycemia.