In 10–15 and 15–20 years of T2DM duration, we observed the appearance of Alpha 1 acid glycoprotein 1, Apolipoprotein A1, transthyretin/prealbumin, Ig kappa C chain region, AMBP, Pigment epithelium-derived factor, Cystatin C, Zinc Alpha 2 glycoprotein and Ubiquitin (Table 3, Fig. 2c, d). This evidence concerns the gene CST3 and type 2 diabetes mellitus.