KCNA3 and arthritic joint disease: On the other hand, Kv1.3-/- rats show thatmaximal T-cell responses against autoantigen or repeated tetanus toxoid stimulationsrequire both Kv1.3 and KCa3.1, since knockdown of Kv1.3 rats developedadjuvant-induced arthritis (AIA) in a manner similar to WT rats, indicating thatthere were no defects in T-cell activation [51].