Forexample, hepatocyte growth factor, one of the important growth factors in the tumormicroenvironment, upregulated the expression of DNA Methyltransferase 1(DNMT1) in HepG2 and non-cancer human liver cells (HL-7702)cells and the overexpression of DNMT1 in HCC patients correlatedwith the malignant potential and poor prognosis [52]. This evidence concerns the gene DNMT1 and hepatocellular carcinoma.