CCND1 and cancer: The genes most affected by BjussuLAAO-II, with an alteration higher than 20% ascompared with non-treated cells, were CDKN1A (Cyclin-DependentKinase Inhibitor 1A), CCND1 (Cyclin D1), andGADD45A (Growth Arrest and DNA-Damage-Inducible 45 Alpha).CDKN1A controls the proliferation, differentiation andtumorigenesis of many cancer cell types and plays a key role in the p53-mediatedcell cycle arrest [40].