CDH1 and cancer: Moreover, reduced EZH2 led to significantly reduced binding of LSD1 (Figure 6C), HDAC1 (Figure 6D), and DNMT1 (Figure 6E) to promoter regions of CDH1, CDKN1A, NEUROD1, and TUBB3, in agreement with increased transcription of these genes in cancer cells after EZH2 knockdown.