Other pan-cancer promoting chromatin modification enzymes include LSD1/KDM1A, HDACs, DNMTs, etc. LSD1 demethylates histone H3 at Lys-4 and Lys-9; HDACs deacetylate lysine residues of core histones; whereas DNMTs catalyze methylation of CpG islands of DNA. The gene discussed is KDM1A; the disease is cancer.