HES1 and cancer: In contrast, proteins that promote various cancer malignant properties, including CCND1, ERBB2, SNAIL, SLUG, phosphorylated STAT3 (p-STAT3), FAK, FOXM1, ETS1, YAP, HES1, and OCT4, were all significantly downregulated (Figure 4F), an indication of reduction of malignancy in the cancer cells after EZH2 knockdown.