Exposure of murine BM-derived MDSC or healthy human PBMCs to TGF-β, along with conditioned medium of either MEER (murine pharyngeal epithelial cells expressing HPV16 E6 and E7, and hRas) or human head and neck squamous cell carcinoma cells (SCC-47), triggered CD11b+Gr1+ MDSCs to acquire antigen-presenting capability and Fas-dependent tumor cells killing activity (68). This evidence concerns the gene ITGAM and neoplasm.