Genetic polymorphisms that can serve as risk factors in sporadic AD include but are not limited to alterations in sortilin-related receptor 1, clusterin, complement component receptor 1, CD2-associated protein (CD2AP), Ephrin type-A receptor 1 protein (EPHA1), and Membrane-spanning 4-domains subfamily A (MS4A6A/MS4A4E genes) (Herrera-Rivero, 2013). The gene discussed is EPHA1; the disease is Alzheimer disease.