SATB1 and acute myeloid leukemia: However, we did not observe a significant increased in the invasiveness of AML cells after knockdown of SATB1. It is difficult to make a conclusion that SATB1 is dispensable for the invasiveness of AML because AML arise as a consequence of a number of genetic aberrations and multiple molecular events; the invasiveness of different subtypes of AML varied and results from only one AML cell line can not tell the whole story.