TRAF2 expression and tumor diameter was statistically significant correlated with OS, with HR 2.071 for TRAF2 (95% CI 1.087–3.94, p = 0.022) and HR 1.814 for tumor diameter (95% CI 1.046–3.146, p = 0.034) according to multivariate Cox regression analysis, indicating the TRAF2 expression together with tumor diameter were independent prognostic factors in GC. The gene discussed is TRAF2; the disease is neoplasm.