One formulation of functionalized liposomes encapsulating p53 plasmid DNA [27] is being evaluated in a phase II study (NCT02340156); the wild-type p53 serves to make the tumors susceptible to chemotherapy, a noteworthy advance for this notoriously chemoresistant tumor type, but still requiring patients to be exposed to chemotherapeutic drugs and their associated toxicities. The gene discussed is TP53; the disease is neoplasm.