MRC1 and neoplasm: We further developed xenograft sorafenib-resistant and sorafenib-sensitive models by passage of HCC cells in nude mice, inducible treatment of mice with sorafenib, and implantation of mouse-passaged tumour cells in mice again.16 We found F4/80+/CD206+ double positive M2 macrophages are significantly higher in SR tumour than that of SS tumour.