In turn, the secreted LOXL2 promotes fibronectin production, MMP9 (Matrix metalloproteinase-9) and CXCL12 (Stromal cell-derived factor 1) expression in lung fibroblasts and increases bone marrow derived cells (BMDCs) motility and invasion, assisting pre-metastatic niche formation and settlement of HCC circulating cells in lung tissues [111]. This evidence concerns the gene LOXL2 and hepatocellular carcinoma.