PRTN3 and thyroiditis: The second patient, already described in Olivieri et al., had a notable immunological involvement which included thyroiditis, cANCA positivity, antiphospholipid antibodies and cerebral ischemia [25]: In addition to the “classic” leukoencephalopathy picture, brain MRI showed at 5 years of age a first ischemic event at the level of the left caudate nucleus and the follow up showed additional lacunar infarct outcomes and slight enlargement of the other homolateral malacic area.