In the placebo group, 21 adverse effects were observed as follows: digestive symptoms (n = 3); injury (n = 1); stomatitis (n = 1); backache (n = 1); skin symptoms (n = 2); toothache (n = 1); urinary occult blood (n = 1); nasal symptoms (n = 3); variation in ALT (n = 1); variation in DBP (n = 1); variation in Hb (n = 1); variation in Ht (n = 1); variation in RBC (n = 1); variation in UA (n = 2); variation in γ-GTP (n = 1). This evidence concerns the gene GPT and stomatitis.