NPC1 and nasopharyngeal carcinoma: This 0.7 mmol/kg dose of Lac-β-CyD was a quarter of the effective dose of HP-β-CyD reported previously (2.8 mmol/kg, 4000 mg/kg).(23) As shown in Figure 2a, vacuolization and lipid-laden macrophages were observed in the livers of control Npc1−/− mice, typical symptoms of hepatomegaly in NPC due to the accumulation of free cholesterol and glycolipids in liver.