To further investigate the expression levels of P-gp and dCK in LLC tumor-bearing mice after the combination administration of GEM and DBD, our western blot and RT-PCT results confirmed the up-regulation of dCK and down-regulation of P-gp in the tumor tissue of the GEM + DBD group mice, while DBD treatment did not alter the expression of hCNTs and hENTs in A549 cells. The gene discussed is DCK; the disease is neoplasm.