TNF and metabolic dysfunction-associated steatotic liver disease: Because Tnf-α belongs to the senescence-associated secretory phenotype (SASP) produced by senescent cells, and that through the SASP, senescence begets senescence, the reduction in essential anti-inflammatory n-3 fatty acids associated with NAFLD may initiate (middle-age adults) or exacerbate (older age) the senescence of brain cells that would then synergize to further their accumulation and prematurely exhaust cognitive reserves.