This striking organotropism change is mediated by the differential epithelial status of tumor cells, i.e., invasive tumor cells in the primary tumor showed low E-cadherin expression but regained in liver metastatic lesions; in contrast, tumor cells in the lung metastases lacked expression of P120CTN or E-cadherin, suggesting the occurrence of MET in liver metastasis, but lung metastatic cells remained at the M state. This evidence concerns the gene CDH1 and neoplasm.