In light of our data, we also postulate that FOXA2 has no role in differentiation of ECs into teratoma, yolk-sac tumors and choriocarcinomas, since FOXA2 and FOXA2-associated differentiation factors are not upregulated during reprogramming of TCam-2 into an EC-like fate, in TCam-2-ΔSOX2, in 2102EP cells in vivo or in non-seminomatous tissues (Figure 4; Figure S4A,B) [7,9]. Here, FOXA2 is linked to yolk sac tumor.