In our previous acute passive transfer experiments, one or two days after the appearance of ALS IgG in the lower motor neurons, activated microglia cells were recruited to the vicinity [15], elevated levels of proinflammatory cytokines TNF-α and Interleukin 6 were found in the spinal cords, and later in the blood too. The gene discussed is IL6; the disease is amyotrophic lateral sclerosis.