A previous report also showed that the anti-pCFH antibodies recognize and bind CFH on the surface of tumor cells, and thereby facilitate the activation of complement system, which in turn damages the tumor cells by both complement-dependent cytotoxicity (CDC) and antibody-dependent complement-mediated cytotoxicity (ADCC), and it ultimately suppresses tumor growth and prevents tumor metastasis [6,7]. The gene discussed is CFH; the disease is neoplasm.