The hs-cTnT is released following myocardial injury due to cardiac ischemia, for example, and possibly also cardiac strain.53 Similarly, NT-proBNP may be a marker of “pancardiac disease”, as it is associated with left ventricular (LV) dysfunction, LV hypertrophy, left atrial dilation, and cardiac ischemia.54 Mechanisms are involved in the relationship between these biomarkers and the GFR in an apparently healthy population that may have subclinical cardiac injury. The gene discussed is TNNT2; the disease is myocardial ischemia.