The two non-MHC GWAS coincident G × cell interaction SNPs are rs1351111, which is coincident with GWAS lead SNPs for Behcets disease (r2 = 1; rs2617170) and whose regulation of KLRK1 [MIM: 611817] is dependent on macrophage proportion,42 and rs4728142, whose regulation of IRF5 [MIM: 607218] is dependent on endothelial proportion and which is the lead SNP in GWASs for a range of auto-immune diseases including ulcerative colitis and systemic lupus erythematous.43, 44. The gene discussed is IRF5; the disease is ulcerative colitis.