Furthermore, elevated IL-6 level constitutes a significant predictor of transition from mild cognitive impairment to Alzheimer’s disease (Bermejo et al. 2008; Ershler and Keller 2000) and progression of this disease in older individuals (Ershler and Keller 2000; Maggio et al. 2006). The gene discussed is IL6; the disease is early-onset autosomal dominant Alzheimer disease.