I.C.V injection of AβO induced phosphorylation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic translation initiation factor 2α (eIF2α) which triggered a decrease of synaptophysin and PSD-95 levels and cognitive impairment in WT mice, but not in TNFR−/− mice [81]. The gene discussed is EIF2AK2; the disease is Cognitive impairment.