Three genes (ARID1A, SOX9, and FAM123B/WTX) were frequently mutated.6 Ashktorab et al analyzed 63 Iranian patients using targeted exome sequencing and found higher mutation rates of MSH3, MSH6, APC, and PIK3CA and hypothesized a larger role for these genes in CRC. Here, MSH3 is linked to colorectal carcinoma.