In conclusion, we identified recurrent mutations in genes such as APC, TP53, KRAS, and FBXW7, as well as unreported mutations in NRAS, PIK3CA, SOX9, APC, SMAD4, MSH3, MSH4, PMS1 PMS2, AXIN2, ERBB2, PIK3R1, TGFBR2, and ATM in a group of Taiwanese CRC patients. Here, AXIN2 is linked to colorectal carcinoma.