In conclusion, we identified recurrent mutations in genes such as APC, TP53, KRAS, and FBXW7, as well as unreported mutations in NRAS, PIK3CA, SOX9, APC, SMAD4, MSH3, MSH4, PMS1 PMS2, AXIN2, ERBB2, PIK3R1, TGFBR2, and ATM in a group of Taiwanese CRC patients. Here, TP53 is linked to colorectal carcinoma.