NTRK1 and neuroblastoma: By contrast, GM1 has a weak capacity to inhibit human neuroblastoma cell proliferation and EGFR phosphorylation.35 However, in mouse fibroblast cells, treatment with GM1 could markedly reduce phosphorylation of PDGFR by excluding the PDGFR from GEM domain.36 Overexpressed GM1 suppresses the TrkA activation by regulating the distribution of receptor from lipid raft fraction to the non‐raft fraction in PC12 cells.37 Here, we found that in GM1 pre‐treated cells, blockage GM1 with CTB cannot restore the cell proliferation ability (Figure S3).