Since the PI3K pathway has been reported to regulate TNT formation in astrocytes46, and since CLU14 (Supplementary Fig. S3F) and YB-1 (Supplementary Fig. S3F) positively correlate with pAKT activity, we next defined relationships between PI3K and these stress chaperones in TNT formation in PCa. This evidence concerns the gene YBX1 and posterior cortical atrophy.