We found that FN1 (r = 0.21, p = 1.57E-05), SERPINE1 (r = 0.22, p = 5.08E-06), and SPARC (r = 0.14, p = 0.006) all had a significant correlation with CRC disease stage, which indicated that these key genes may have crucial role in GAC progression. This evidence concerns the gene SERPINE1 and colorectal carcinoma.