APC and metastatic neoplasm: Remarkably, and in contrast to Apc-Ras clones, we found Apc-Ras-Sna metastatic tumors (TMets) in multiple distant locations outside the gut, including the abdomen, thorax, and head (Fig. 1a, b, arrows), as well as the ovaries and legs, within 2–3 weeks of induction (Fig. 1c, arrows).