One-month post-treatment DEGs were enriched for both IRG (28%, p < 0.001) and IRG-I (17%, p = 0.013), while the two-month visit was not enriched for either IRG (24%, p = 0.579) or IRG-I (13%, p = 0.747) (Fig. 4c, Supplementary Table 13 and Supplementary Fig. 11), consistent with early elevation of IFN-α2a after schistosomiasis therapy (Fig. 3g). This evidence concerns the gene IFNA2 and schistosomiasis.