In this model, other receptors known to mediate C. albicans endocytosis, such as E-cadherin19,20, N-cadherin21 and EphA222, may be sufficient in compensating in the absence of EGFR function, thus allowing for subsequent infection of tissues to provide a functional model for investigation of C. albicans-induced immune responses. The gene discussed is EGFR; the disease is infection.