Importantly, candidalysin-deficient C. albicans strains (ece1Δ/Δ and ece1Δ/Δ+ECE1Δ184–279 (grey bars)) were unable to induce EREG or EPG shedding (Fig. 4g, h), and less able to induce AREG shedding (Fig. 4i), when compared with candidalysin-expressing strains (WT and ece1Δ/Δ+ECE1 (black bars)); NRG2-4 were not detected following infection with any strain. The gene discussed is ECE1; the disease is infection.