MAP1LC3A and cardiac hypertrophy: In this study, we presented both in vivo and in vitro evidence that the protective effects of oridonin on cardiac hypertrophy were mediated through motivation of autophagy, as oridonin (1) facilitated the formation of LC3-positive autophagosomes and (2) coordinated the core molecular machinery ATG proteins covering the fusion and maturation and degradation of autophagosomes; (3) its protective effects on myocyte hypertrophy were eliminated by autophagy inhibition using 3-MA.