ZC3H12A and Splenomegaly: It is possible that Regnase-1 compensates for Regnase-3 deficiency under certain conditions, given that Regnase-1 plays a role in macrophages: LysM-Cre–specific deletion of Regnase-1 leads to splenomegaly, increased cytokine secretion, and lung injury upon LPS challenge (Li et al., 2017).