However, phenotypic manifestations clearly show that a major, if not the primary, role of Regnase-1 is within the immune system: namely, preventing autoimmunity and ensuring pathogen defense (Iwasaki et al., 2011; Uehata et al., 2013; Mino and Takeuchi, 2015; Habacher and Ciosk, 2017). Here, ZC3H12A is linked to Autoimmunity.