In humans, ID3 and its SNP (rs11574, related to carotid intima-media thickness) have been demonstrated to be associated with coronary heart disease, as measured by coronary artery calcium, a predictor of coronary disease burden [94], and with atheroma burden by intravascular ultrasound [95] in non-Hispanic White, African American, and Hispanic populations [96, 97]. The gene discussed is ID3; the disease is coronary artery disorder.