First, we compared the fraction of lymphocytes estimated by quanTIseq, computed by summing up the cell fractions of B cells, NK cells, CD4+ and CD8+ T cells, and Treg cells, with the “lymphocyte score”, a semi-quantitative measure of the number of tumor-infiltrating lymphocytes estimated previously from H&E-stained section slides of melanoma tumors (n = 468) [48]. Here, CD8A is linked to neoplasm.