In summary, our results obtained using quanTIseq on bulk RNA-seq data from the TCGA suggests that the activation of the CXCR3/CXCL9 axis, rather than the genotype of the tumor, is associated with intratumoral cytotoxic T cells infiltration, and challenges the previous notion that the mutational burden is strongly associated with an increased infiltration of immune cells [51]. The gene discussed is CXCL9; the disease is neoplasm.