Enzalutamide in combination with either pharmacological inhibition of USP14 with IU1 or shRNA-mediated USP14 knockdown were able to more effectively reduce tumor volumes and tumor weights than treatment with enzalutamide or USP14 inhibition alone, without discernibly altering mouse body weights, which also suggests that the two drug regimen is safe and well-tolerated. This evidence concerns the gene USP14 and neoplasm.