The inherited variations at rs17336602 (G>C), rs4770489 (A>G), and rs34354770 (A>C) that were highly linked with the tag-SNP rs753955 (A>G) significantly weakened the enhancer activity by impairing its p53 responsiveness, empowering the potential lung cancer suppressive TNFRSF19 to decrease its eQTL gene expression. This evidence concerns the gene TNFRSF19 and lung carcinoma.