The inherited variations at rs17336602 (G>C), rs4770489 (A>G), and rs34354770 (A>C) that were highly linked with the tag-SNP rs753955 (A>G) significantly weakened the enhancer activity by impairing its p53 responsiveness, empowering the potential lung cancer suppressive TNFRSF19 to decrease its eQTL gene expression. Here, TNFRSF19 is linked to lung cancer.