IL6 and cancer: It has been confirmed that EMT is a crucial step in the migration of cancer cells, which is controlled by different signaling transduction pathways and networks, such as autocrine IL11/IL6-gp130/JAK2/STAT, fibronectin-integrin, GAS6-Axl/Tyro3, PDGFR/FGFR/RET, and TGF-β R networks [20].