Recently, it was reported that the mitochondrial protein, B-cell lymphoma 2 (BCL-2) interacting protein 3 (BNIP3) in melanoma potentially supported mitochondrial fission and turnover through stimulating mitophagy by directly binding to both mitochondria and the autophagosomal protein LC3, but also maintained cellular architecture and enhanced cytoskeleton polymerization [131], which revealed the pro-tumorigenic role of BNIP3 in driving EMT and melanoma cell’s migration. Here, BNIP3 is linked to melanoma.