HIF1A and cancer: Mechanically, hypoxia-induced phosphatidylinositol (4,5) bisphosphate (PIP2) level increased in cancer cells by activating the HIF-1α/RhoA/ROCK1 signaling pathway supported actin filament (F-actin) expression and attenuate the binding amounts of F-actin and capping actin protein of muscle Z-line alpha subunit 1 (CAPZA1), which in turn enhanced EMT [123, 124].