Moreover, studies about breast and colon cancers have described that the death effector domain-containing DNA-binding protein (DEDD) not only significantly represses EMT by inducing autophagy through direct interaction with the class III PI-3 kinase (PI3KC3)/Beclin-1 but also promotes the autophagy-mediated lysosomal degradation of SNAIL and TWIST [135, 136]. The gene discussed is TWIST1; the disease is malignant colon neoplasm.