In a further study, Beclin-1 gene knockout or low expression is involved in the activation of WNT1 and NF-κB, leading to cancer cell metastasis, which suggests that the knockout or low expression of the Beclin-1 gene may promote EMT and cancerogenesis by activating the WNT1 pathway, resulting in poor prognosis [63, 64]. Here, BECN1 is linked to cancer.