To evaluate the TRAIL sensitivities of various sarcoma cell lines, undifferentiated pleomorphic sarcoma (UPS; MFHino), liposarcoma (LPS; SW872), and fibrosarcoma (FS; HT1080) cell lines were treated with increasing doses of rhTRAIL. The gene discussed is TNFSF10; the disease is undifferentiated pleomorphic sarcoma.