To observe whether the Angptl3 knockout plays a similar renal protective role in the end stage of nephropathy, we compared differences in proteinuria, hypoproteinemia, renal function, general condition (weight, fur quality, activity and appetite) and survival rates among different experimental groups at different time points up to 12 weeks in our ADR nephropathy mouse model. Here, ANGPTL3 is linked to Nephropathy.