Our previous work revealed increased Angptl3 expression in the glomeruli of children with nephrotic syndrome (including minimal change disease and glomerulosclerosis) and animal models of Adriamycin (ADR) nephropathy, and in ADR- or puromycin aminonucleoside (PAN)- treated cultured podocytes [12–16]. Here, ANGPTL3 is linked to glomerulosclerosis.