As a significant increased 18F-PSMA uptake over time was demonstrated in PCa lesions with a higher contrast at delayed PET/CT time points compared to early PET/CT time points [23,24,25,26], it is not recommended to perform 18F-PSMA PET/CT at 60 min after radiotracer injection (which is the common imaging time point for 68Ga-PSMA PET/CT). This evidence concerns the gene FOLH1 and posterior cortical atrophy.