K8 and K18 also function in the liver to help hepatocytes cope with mechanical and nonmechanical stress that can result in apoptosis and necrosis [93,94], and a recent study by Bozza et al. also showed that K8 and K18 protect breast cancer cells from TRAIL-induced apoptosis by downregulating death receptor expression (Figure 2A) [95]. The gene discussed is KRT18; the disease is breast carcinoma.