Similarly, formation of liver cancer by co-injection of transposons encoding tumor oncogene YAP and p53 shRNA into mice was abrogated when nestin shRNA was co-injected [64] and administering nestin siRNA by subcutaneous injection decreased tumor volume of human pancreatic cancer cell line KLM-1 in nude mice (Table 1) [67]. This evidence concerns the gene NES and pancreatic neoplasm.