NKX2-5 and neoplasm: Besides, the microenvironment factor IL2 could trigger TF NKX2-5 through signaling transduction proteins TMED3 and TF NKX2-5 to positively regulate target genes RAP2C and JMY, which were modified by DNA methylation with a higher basal level in normal than early stage of PTC, and then the target gene JMY could promote tumor cells’ apoptosis.