For the core signaling pathways of early-stage thyroid cancer cells in Figure 1, the receptor TGFBR3 was activated by the transforming growth factor TGFB1 (cell development signaling) to modulate TF CEBPB to positively regulate gene PARD6B, which was also suppressed by MIRLET7C, to promote tumor cell proliferation through the mediation of signaling transduction proteins AKAP6, RASA2, and S100A9. This evidence concerns the gene S100A9 and thyroid cancer.