Then, mutated TF NKX2-5 could positively regulate target genes MIR29C and MIRLET7B. TF NKX2-5 could be translocated to the nucleus, which was negatively regulated by MIR130A. Therefore, the target gene NKX2-5 could be modified by DNA methylation to suppress cancer cell differentiation. Here, MIR130A is linked to cancer.