In the tumor necrosis factor TNF family, ligand member TNFSF10 (a regulation signal of extrinsic apoptotic signaling pathway) is mainly expressed in the cells of the immune system or oncogenic transformed cells, and it could induce apoptosis of thyroid cancer cells through interaction with the receptor TNFRSF10B [46]. This evidence concerns the gene TNFRSF10B and thyroid cancer.