PIK3CA and cancer: Furthermore, mutated PIK3CA could regulate TF NKX2-5 and induce the mutation of NKX2-5 via EIF2B5 and CKS1B, and then the mutated NKX2-5 is translocated into the nucleus and is regulated by MIR130A. The target gene NKX2-5 is up-regulated in the nucleus due to DNA methylation, and its overexpression promotes the proliferation of cancer cells to induce the inhibition of cancer cell differentiation during thyroid carcinogenesis.