MAP2K1 and cancer: Besides, the translocated target gene AFAP1L2 was also suppressed by MIR30D to promote cell proliferation and migration; the target gene RAP2C, which was modified by DNA methylation with a higher basal level at equation (2) in Supplementary Materials 1.1, could induce cancer migration; the target gene ALG2 could cause tumor cell proliferation and migration; the target gene MAP2K1, which was also suppressed by MIR34A, could lead to cancer cell proliferation and tumor cell cycle; the target gene CD151 was affected by DNA methylation to promote thyroid cancer cell migration and angiogenesis.