Since ERK1/2 interacts with the caveolae through caveolin 1, which, with its partner cavin-1, facilitates the recruitment of ERK1/2 to caveolae to balance ERK signalling and other types of signalling, ERK signalling in turn enhances growth and metastasis formation in tumours [12,13,14]. Here, MAPK1 is linked to neoplasm.