This sub-cohort was further stratified between PSA level at diagnosis ≤20 or >20, Gleason sum <8 and ≥8, PC anatomic stage/prognostic group <IIB and ≥IIB, those receiving no ADT vs those receiving ADT, and those receiving RP or no RP, both with and without further stratification, based on the AKR1C3 rs12529 genotype (Table 5). Here, KLK3 is linked to pachyonychia congenita.