The p53 family of tumor suppressors trigger autophagy in mammalian cancer cells in response to genotoxic and/or environmental stimuli, mediated by the nutrient energy sensor AMP-activated protein kinase (AMPK), by inhibition of the mammalian target of rapamycin (mTOR), and by induction of the autophagy modulator DRAM1 [71, 72]. Here, DRAM1 is linked to neoplasm.