Interestingly, analysis of patient tumor expression using the GOBO database [32] revealed that the genes within this signature, weighted for expression direction and relative contribution to the signature using the mouse-calculated hazard ratios and grouped by their cumulative signature score, are also able to predict distant metastasis-free survival in breast cancer patients of the Her2-enriched subtype (S1C Fig), suggesting that our approach is able to identify haplotypes relevant to outcome in patients as well as in mice. The gene discussed is ERBB2; the disease is breast carcinoma.