Additionally, the progression of Alzheimer's disease is accompanied by the loss of CK‐BB activity as well as increased levels of PCr.60, 61 Decreased activity of CK‐BB in Alzheimer's disease may be caused by the oxidative modification of CK‐BB in the post‐translational stage through ROS, which could be generated in hypoxic conditions.62, 63. Here, CKB is linked to early-onset autosomal dominant Alzheimer disease.