Although pituitary carcinomas have not been reported in patients with AIP mutations, they have been observed in other genetic pituitary adenoma predisposition syndromes [MEN1 (20, 21), SDHB (22), AIP mutation‒negative familial isolated pituitary adenoma (23, 24)] and in one patient with Lynch syndrome (25). This evidence concerns the gene AIP and pituitary adenocarcinoma.